Metastasis is a Greek word that translates to change of place in the English language. In cancer metastasis research, tumor metastasis refers to the process of movement of tumor cells from original site of the cancer to other parts within the body. This process is fairly complex and according to modern research, it is only partially understood. Research at molecular and biochemical levels has yet to come up with a complete understanding of this process.
Many types of cancers may be sufficiently treated by employing surgery and radiotherapy. The two forms of treatment may be successfully employed in the destruction or removal of primary tumors. Nevertheless, mortality and morbidity in most patients are as a result of the movement of malignant cells. Treatment of the disease would be easier if a method can be found for stopping metastasis from happening.
Scientists often make a comparison of the process of metastasis to marathon. Upon the development of malignant tissues, they begin to infest solid tissues around them. Body tissues contain a variety of cells and are very complex. For instance, body tissues have fibroblasts. These cells offer lymphatic drainage, support, and immune cells. They give a barrier that must be infiltrated by tumor cells. Malignant cells adapt to the presence of this barrier by developing the ability to move.
Malignant cell movement is not a strange event. Cells crawl, as opposed to floating out of the tissue. They achieve this by fundamentally acting in response to environmental factors. They stretch their finger-like projections that enable their forward movement. For them to move, they must change their capacity to stick to other body cells and protein matrix in the body.
Studies hold that the metastasis process is largely inefficient. Only 0.01 percent of malignant cells that make their way into the blood stream result in metastasis. Nevertheless, scientists still lack the capacity to tell if and when malignant cells will end up being metastatic. At the time of treatment, cancer evaluations are normally founded on the capacity of the cells to get metastatic.
As a result, the patient gets treatment tailored to the capacity of the cancer they suffer from to become metastatic. Advanced cancers have an increased chance of getting metastatic when compared to early cancers. As such, progressive cancers are normally treated with more aggression as opposed to those in initial stages. Malignant cells normally get metastatic via two main avenues. These are lymphatic vessels and the bloodstream.
Most cancer cells usually prefer escaping through the lymphatic drainage system. That is why a doctor will usually take a biopsy of the lymphatic nodes to determine if cancerous cells have spread. From the lymphatic vessels, the cells can then enter the bloodstream. Besides entering the bloodstream from lymphatic vessels, cancerous cells can also enter the blood stream directly from blood vessels in the primary tumor.
Many malignant cells die upon getting into the blood stream since the environment inside the vessels is harsh. This is because it has blood flowing fast and has immune cells. The malignant cells are deposited in a number of organs where they begin developing into tumors.
Many types of cancers may be sufficiently treated by employing surgery and radiotherapy. The two forms of treatment may be successfully employed in the destruction or removal of primary tumors. Nevertheless, mortality and morbidity in most patients are as a result of the movement of malignant cells. Treatment of the disease would be easier if a method can be found for stopping metastasis from happening.
Scientists often make a comparison of the process of metastasis to marathon. Upon the development of malignant tissues, they begin to infest solid tissues around them. Body tissues contain a variety of cells and are very complex. For instance, body tissues have fibroblasts. These cells offer lymphatic drainage, support, and immune cells. They give a barrier that must be infiltrated by tumor cells. Malignant cells adapt to the presence of this barrier by developing the ability to move.
Malignant cell movement is not a strange event. Cells crawl, as opposed to floating out of the tissue. They achieve this by fundamentally acting in response to environmental factors. They stretch their finger-like projections that enable their forward movement. For them to move, they must change their capacity to stick to other body cells and protein matrix in the body.
Studies hold that the metastasis process is largely inefficient. Only 0.01 percent of malignant cells that make their way into the blood stream result in metastasis. Nevertheless, scientists still lack the capacity to tell if and when malignant cells will end up being metastatic. At the time of treatment, cancer evaluations are normally founded on the capacity of the cells to get metastatic.
As a result, the patient gets treatment tailored to the capacity of the cancer they suffer from to become metastatic. Advanced cancers have an increased chance of getting metastatic when compared to early cancers. As such, progressive cancers are normally treated with more aggression as opposed to those in initial stages. Malignant cells normally get metastatic via two main avenues. These are lymphatic vessels and the bloodstream.
Most cancer cells usually prefer escaping through the lymphatic drainage system. That is why a doctor will usually take a biopsy of the lymphatic nodes to determine if cancerous cells have spread. From the lymphatic vessels, the cells can then enter the bloodstream. Besides entering the bloodstream from lymphatic vessels, cancerous cells can also enter the blood stream directly from blood vessels in the primary tumor.
Many malignant cells die upon getting into the blood stream since the environment inside the vessels is harsh. This is because it has blood flowing fast and has immune cells. The malignant cells are deposited in a number of organs where they begin developing into tumors.
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